Then they used computer algorithms to figure out which genes belonged to which organism.
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by Jindong Zan, Zhiyuan Li, Ma Diarey Tianero, Jeanette Davis, Russell T Hill, Mohamed S Donia. Diarey tianero scholar Diarey tianero scholar free Through this method they identified the new bacterial species and linked it to the production of the toxins.
reuteri, together with a tryptophan-rich diet, can reprogram intraepithelial CD4+ T cells into immunoregulatory T cells. A microbial factory for defensive kahalalides in a tripartite marine symbiosis. reuteri did not shape the DP-IEL-TCR (TCR, T cell receptor) repertoire but generated indole derivatives of tryptophan that activated the aryl-hydrocarbon receptor in CD4+ T cells, allowing Thpok down-regulation and differentiation into DP IELs. This species induced DP IELs in germ-free mice and conventionally-raised mice lacking these cells. We found that DP IEL numbers in mice varied in different vivaria, correlating with the presence of Lactobacillus reuteri. DP IELs are absent in germ-free mice, which suggests that their differentiation depends on microbial factors. The small intestine contains CD4+CD8αα+ double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4+ T cells through down-regulation of the transcription factor Thpok and have regulatory functions.
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